Today, virtually any advance in the life sciences requires a sophisticated mathematical approach. The methods of mathematics and computer science have emerged as critical tools to modeling biological phenomena, understanding patterns, and making sense of large data sets, such as those generated by the human genome project. An Invitation to Biomathematics provides a comprehensive, yet easily digested entry into the diverse world of mathematical biology--the union of biology, mathematics, and computer science.
This textbook, expertly written by a team of experienced educators, is divided into two parts. The first section presents core principles as elucidated by classical problems such as population growth, predator-prey interactions, epidemic models, and population genetics, while the second applies these principles to modern biomedical research. In addition, the supplementary work Laboratory Manual of Biomathematics (available separately) is designed to enable hands-on exploration of model development, model validation, and model refinement.
* Provides a complete guide for development of quantification skills crucial for applying mathematical methods to biological problems.
* Includes well-known examples from across disciplines in the life sciences including modern biomedical research.
* Explains how to use data sets or dynamical processes to build mathematical models.
* Offers extensive illustrative materials.
* Written in clear and easy-to-follow language without assuming a background in math or biology.
* A laboratory manual is available for hands-on, computer-assisted projects based on material covered in the text.

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

The use of thermodynamics in biological research can be equated to an energy book-keeping system. While the structure and function of a molecule is important, it is equally important to know what drives the energy force. These methods look to answer: What are the sources of energy that drive the function? Which of the pathways are of biological significance? As the base of macromolecular structures continues to expand through powerful techniques of molecular biology, such as X-ray crystal data and spectroscopy methods, the importance of tested and reliable methods for answering these questions will continue to expand as well. This volume presents sophisticated methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions.

* Elucidates the relationships between structure and energetics and their applications to molecular design, aiding researchers in the design of medically important molecules * Provides a "must-have" methods volume that keeps MIE buyers and online subscribers up-to-date with the latest research * Offers step-by-step lab instructions, including necessary equipment, from a global research community

The combination of faster, more advanced computers and more quantitatively oriented biomedical researchers has recently yielded new and more precise methods for the analysis of biomedical data. These better analyses have enhanced the conclusions that can be drawn from biomedical data, and they have changed the way that experiments are designed and performed. This volume, along with previous and forthcoming "Computer Methods" volumes for the Methods in Enzymology serial, aims to inform biomedical researchers about recent applications of modern data analysis and simulation methods as applied to biomedical research.

* Presents step-by-step computer methods and discusses the techniques in detail to enable their implementation in solving a wide range of problems * Informs biomedical researchers of the modern data analysis methods that have developed alongside computer hardware *Presents methods at the "nuts and bolts" level to identify and resolve a problem and analyze what the results mean

In the past several years, there has been an explosion in the ability of biologists, molecular biologists and biochemists to collect vast amounts of data on their systems. This volume presents sophisticated methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions.
The use of thermodynamics in biological research is used as an energy book-keeping system. While the structure and function of a molecule is important, it is equally important to know what drives the energy force. These methods look to answer: What are the sources of energy that drive the function? Which of the
pathways are of biological significance? As the base of macromolecular structures continues to expand through powerful techniques of molecular biology, such as X-ray crystal data and spectroscopy methods, the importance of tested and reliable methods for answering these questions will continue to expand as well."

The combination of faster, more advanced computers and more quantitatively oriented biomedical researchers has recently yielded new and more precise methods for the analysis of biomedical data. These better analyses have enhanced the conclusions that can be drawn from biomedical data, and they have changed the way that experiments are designed and performed.
This volume, along with previous and forthcoming 'Computer Methods' volumes for the Methods in Enzymology serial, aims to inform biomedical researchers about recent applications of modern data analysis and simulation methods as applied to biomedical research.

Fluorescence spectroscopy is a type of electromagnetic spectroscopy, using a beam of light, which analyzes fluorescence from a sample. Given its extremely high sensitivity and selectivity, it is an important investigational tool in many areas including material sciences, analytical sciences, and across a broad range of chemical, biochemical and medical research. It has become an essential investigational technique allowing detailed, real-time observation of the structure and dynamics of intact biological systems. The pharmaceutical industry uses it heavily and it has become a dominating technique in biochemistry and molecular genetics.
* Keeps MIE buyers and online subscribers up-to-date with the latest research with this highly used technique.
* Provides tried and tested techniques which eliminate searching through many different sources.

The aim of this volume is to brief researchers of the importance of data analysis in enzymology, and of the modern methods that have developed concomitantly with computer hardware. It is also to validate researchers' computer programs with real and synthetic data to ascertain that the results produced are what they expected.
Selected Contents: Prediction of protein structure; modeling and studying proteins with molecular dynamics; statistical error in isothermal titration calorimetry; analysis of circular dichroism data; model comparison methods

This volume focuses on methods related to allosteric enzymes and receptors, including fluorescent proves, spectroscopic methods and quantitative analysis as well as on cooperativity in protein folding. NMR and mass spectrometry methods are discussed.
*Allosteric Enzymes and Receptors
*Cooperativity in Protein Folding and Assembly

In this volume contemporary methods designed to provide insights into, mathematical structure for, and predictive inferences about neuroendocrine control mechanisms are presented.
Key Features
* Collates an array of contemporary techniques for analysis of neuroendocrine data
* Discusses current problems in and solutions to neurohormone pulse analysis
* Identifies relevant software available

This is the first book to explore the opportunities deconstruction opens up for the teaching of both composition and literature. It is a unique and timely response to crucial issues facing teachers of composition and literature at all levels: high school, college, and university. "The critical rage" (and likely to remain so), deconstruction is the most controversial and arguably the most promising critical-theoretical movement of recent decades. It has proven to be enormously influential as a strategy of textual analysis, thanks in large part to the enterprise of such critics as J. Hillis Miller, Geoffrey H. Hartman, Barbara E. Johnson, and Gayatri Chakravorty Spivak, all of whom are contributors to this collection. The implications of deconstruction for the teaching of both writing and reading are just now being explored, however. These groundbreaking essays exemplify and assess that potential. The scope of consideration is wide. The essays all discuss deconstruction, treat its pedagogical implications, and evaluate its impact upon the teaching of composition and literature. In doing so, the contributors address specific questions concerning "the literary crisis" and "the crisis in literary studies" and offer a reasoned, balanced, and provocative account of the usefulness of deconstruction in solving at least some of the problems that beset the profession.

The use of thermodynamics in biological research can be equated to an energy book-keeping system. While the structure and function of a molecule is important, it is equally important to know what drives the energy force. This volume presents sophisticated methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions.

* Elucidates the relationships between structure and energetics and their applications to molecular design, aiding researchers in the design of medically important molecules * Provides a "must-have" methods volume that keeps MIE buyers and online subscribers up-to-date with the latest research * Offers step-by-step lab instructions, including necessary equipment, from a global research community

Just what was so wild about the Wild West?

Americans have had an enduring yet ambivalent obsession with the West as both a place and a state of mind. Now one of the most knowing observers of the Western scene offers a monumental cultural and historical analysis of how ideas of wildness have shaped the ways Euro-Americans have perceived, reacted to, and acted upon the West for nearly five hundred years. Bringing the sensibility of a poet to a sweeping discussion of place, Michael L. Johnson considers how that obsession originated, how it has determined attitudes toward and activities in the West, and how it has changed over the centuries.

Investigating views of Western wildness from pre-European times until the present, Johnson tells how explorers and settlers bent on exploiting the West brought with them Old World ideas, full of muddled and even bizarre contradictions, that have defined the region in its most fundamental aspects. And he shows how those contradictory ideas were woven into an ambivalent ideology of conquest that has given us today's degraded wilderness areas, overtaxed water supplies, and sprawling suburbs.

Brimming with word-play, personal anecdotes, and telling vignettes, Hunger for the Wild provocatively addresses a cornucopia of Western personalities, phenomena, and events. Invoking a vast array of writers and thinkers-from Claude Lvi-Strauss to Black Elk to Richard Etulain-Johnson casts his critical eye on conquistadors and cowboys and revisits myths of Noble Savage and "red devil" alike. His kaleidoscopic text examines Dust Bowl woes and Wild West shows, and whether contemplating the Disneyfied frontier or the Ralphlaurenized range, he takes readers on an intellectual romp through the wilds of the contemporary West, with its UFO fanatics and postregional cowgirls.

Emphasizing his call for seeing the West as "a place of roots as well as routes," Johnson's tour de force marks a major contribution to the deeper history of the region and points toward a more sustainable West for the future. It should interest not only Western historians but also art and film buffs, ecocritics, cross-cultural specialists, and rodeo fans-anyone fascinated by the wild, Western-style.

Grundlagen der Computergrafik und des Geometrischen Modellierens werden mit diesem Buch dargestellt. Es behandelt neuere rasterbasierte Techniken (z.B. Texturmapping und Anti-Aliasing), die in modernen Grafikbibliotheken und Grafikkarten von PCs ublich sind. Daneben werden Ray-Tracing und Radiosity Methoden und objektraum-definierte Modelliertechniken, sowie effiziente Algorithmen der Geometrie grundlegend besprochen. Zu den einzelnen Kapiteln sind Ubungsaufgaben angefuhrt.

Winner: Spur Award, Best Western Nonfiction "Yeeeeehaaah!" Nightly that raucous cry breezes out from beneath the broad-brimmed Stetsons of boot-scootin line dancers at boisterous bars called Cadillac Ranch, Cactus Moon, or Stallions & Stars. And that, Michael Johnson tells us, is just one of the many signs that Americans have rekindled--and refashioned--their love affair with the American West. These "New Westers," Johnson reveals, line-dance and two-step, listen to Garth Brooks and George Strait, drink beer from long-neck bottles, wear clothes ordered from Sheplers, watch rodeo on ESPN, play Wild West arcade games, eat fajitas and tacos in stucco-style Mexican cafes, collect Western art and Native American crafts, and vacation in and move to the West. "New Westers" rewrite the history and biography of the West. They re-imagine the West in cowboy sagas and poetry, Native American novels, Mexican-American drama, nature writing, revisionist films, eclectic visual artwork, and neo-traditional music. They flock to movies like Thelma and Louise, Unforgiven, and Dances with Wolves or mini-series like Lonesome Dove and read bestsellers like The Crossing and All the Pretty Horses. "New Westers" are men and women who may or may not have ever hitched up a horse but who want a "personal" West. At the end of an urbanized century adrift in confusing change, they seek a more natural home, a fuller and wider sense of place, and a deeper and more colorful personal identity. They also want, Johnson shows, to revive the dream of the mythic West--but on new and different terms. They overrun the Old West and yet strive to preserve it, raising troubling new concerns about the differences between the mythic and the real, between traditional and contemporary cultural influences. Infused with true grit and true affection, Johnson's immensely entertaining book takes us on a lively jaunt through a colorful and amazing landscape. His celebration of things Western will be treasured by all armchair cowpokes or anyone who's ever dreamed of riding the high country.

The camp, as it is referred to by most of the inmate's today is a completely self contained large farm like place where the inmate's have to raise and grow almost everything they need to survive. There are no roads visible getting to the camp, in fact there hasn't been any kind of automobiles in the camp since it was built. The only way into it is by helicopter or air plane, and of course this has given way to a lot more rumors about the place. Although over the years many of them have got to be pretty ridiculous, and far from true.

The use of computers and computational methods has become ubiquitous in biological and biomedical research. During the last 2 decades most basic algorithms have not changed, but what has is the huge increase in computer speed and ease of use, along with the corresponding orders of magnitude decrease in cost.

A general perception exists that the only applications of computers and computer methods in biological and biomedical research are either basic statistical analysis or the searching of DNA sequence data bases. While these are important applications they only scratch the surface of the current and potential applications of computers and computer methods in biomedical research. The various chapters within this volume include a wide variety of applications that extend far beyond this limited perception. As part of the Reliable Lab Solutions series, Essential Numerical Computer Methods brings together chapters from volumes 210, 240, 321, 383, 384, 454, and 467 of Methods in Enzymology. These chapters provide a general progression from basic numerical methods to more specific biochemical and biomedical applications.

The various chapters within this volume include a wide variety of applications that extend far beyond this limited perception. As part of the Reliable Lab Solutions series, Essential Numerical Computer Methods brings together chapters from volumes 210, 240, 321, 383, 384, 454, and 467 of Methods in Enzymology. These chapters provide a general progression from basic numerical methods to more specific biochemical and biomedical applications.

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 270 volumes have been published (all of them still in print) and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences.
Key Features
* Fluorescence in biophysics
* Fluorescence as a tool for studying proteins
* Determination of ground-state dissociation constant by fluorescence spectroscopy
* Fluorescence spectroscopy of protein-protein and protein-nucleic acid interactions
* Fluorescence methods for studying equilibrium macromolecule-liquid interactions
* Methods for detecting molecular clusters on cell surfaces

The aim of this volume is to brief researchers of the importance of data analysis in enzymology, of the modern methods that have developed concomitantly with computer hardware, and of the need to validate their computer programs with real and synthetic data to ascertain that the results produced are what they expected.